Water → Acetic acid, [(1-thioxoethyl)thio]-, ethyl ester

Temperature

40 °C

Methyl magnesium chloride (10 mL, 3M solution in THF) was diluted with THF (10 mL) and the resulting solution warmed to 40° C. Carbon disulfide (2.28 g, 0.03 mol) was added over 10 minutes while maintaining the reaction temperature at 40° C. The reaction was cooled to room temperature before adding ethyl bromoacetate (5.01 g, 0.03 mol) over 15 minutes. The reaction temperature was increased to 50° C. and maintained for a further 4 hours. Water (100 mL) was added and the organic products were extracted with ethyl acetate (3×60 mL). The combined organic extracts were washed with water, brine and dried over anhydrous magnesium sulfate. After removal of solvent and column chromatography (Kieselgel-60, 70-230 mesh, 10% diethyl ether in n-hexane eluent), pure ethoxycarbonylmethyl dithioacetate was obtained as a golden oil (1.3 g, 24.3% yield). 1H-nmr (CDCl3) d (ppm): 1.25 (t, 3H); 2.90 (s, 3H); 4.07 (s, 2H) and 4.20 (q, 2H).

1. temperaturewhile maintaining the reaction temperature at 40° C
2. temperatureThe reaction was cooled to room temperature
3. temperatureThe reaction temperature was increased to 50° C.
4. temperaturemaintained for a further 4 hours
5. extractionthe organic products were extracted with ethyl acetate (3×60 mL)
6. washThe combined organic extracts were washed with water, brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customAfter removal of solvent and column chromatography (Kieselgel-60, 70-230 mesh, 10% diethyl ether in n-hexane eluent)

ORD record

ord-5c1dd07fcc4f40ce83df66ebcf45b3b5

Source dataset

uspto-grants-2010_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07666962B2