HRID1445981

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2758520

N,1-dimethylpyrrolidin-3-amine

C6H14N2

结构：COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O

HCID9867340

未命名化合物

PRODUCTS

生成物

结构：COC[C@H]1OC(=O)/C(=C/N(C)C2CCN(C)C2)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@@]4(C)C3CC[C@@H]4O)[C@]21C

HCID11512258

未命名化合物

收率 38.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 27.4 mg (0.24 mmol) N,N′-dimethyl-3-aminopyrrolidine. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with Et2O to give 25 mg (38%) product as an orange powder.

WORKUP

后处理

customCH2Cl2 is removed in vacuo
customThe residue is triturated with Et2O

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e0c3e1d909184f1f902433fe0c7071c5
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07666901B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH3:1][C:2]([O:4][C@H:5]1[C:14]2[C@@:15]3([CH3:30])[C@@H:26]([CH2:27][O:28][CH3:29])[O:25][C:23](=[O:24])[C:17]4=[CH:18][O:19][C:20]([C:21](=[O:22])[C:13]=2[C@@H:8]2[CH2:9][CH2:10][C@H:11]([OH:12])[C@@:7]2([CH3:31])[CH2:6]1)=[C:16]34)=[O:3].[CH3:32][NH:33][CH:34]1[CH2:38][N:37]([CH3:39])[CH2:36][CH2:35]1>C(Cl)Cl>[C:2]([O:4][C@H:5]1[C:14]2[C@:15]3([CH3:30])[C:16](/[C:17](=[CH:18]\[N:33]([CH3:32])[CH:34]4[CH2:35][CH2:36][N:37]([CH3:39])[CH2:38]4)/[C:23](=[O:24])[O:25][C@@H:26]3[CH2:27][O:28][CH3:29])=[C:20]([OH:19])[C:21](=[O:22])[C:13]=2[CH:8]2[C@@:7]([CH3:31])([C@@H:11]([OH:12])[CH2:10][CH2:9]2)[CH2:6]1)(=[O:3])[CH3:1]