N,1-dimethylpyrrolidin-3-amine → (1e,4s,4Ar,5r,6as,7s)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-1-{[methyl(1-methylpyrrolidin-3-yl)amino]methylene}-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate

Participants

Reaction Steps

To a solution of 50 mg (0.12 mmol) 17-hydroxywortmannin in 0.5 mL CH2Cl2 is added 27.4 mg (0.24 mmol) N,N′-dimethyl-3-aminopyrrolidine. The reaction mixture is stirred at room temperature overnight. CH2Cl2 is removed in vacuo. The residue is triturated with Et2O to give 25 mg (38%) product as an orange powder.

Provenance & Evidence