反应详情

温度

140 °C

A mixture of 2-(4-chlorophenyl)-1-(3,4-difluoro-2-hydroxy-phenyl)-4-methyl-pentane-1,3-dione (3.65 g, 10.3 mmol) in acetic acid (36 ml) and concentrated HCl solution (2 ml) is stirred at 140° C. for 3 h. The reaction mixture is cooled to room temperature, poured onto ice-water and extracted with methylene chloride. The organic layer is washed with saturated sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate and evaporated to dryness in vacuo to afford the title compound as a brown solid.

1. temperatureThe reaction mixture is cooled to room temperature
2. additionpoured onto ice-water
3. extractionextracted with methylene chloride
4. washThe organic layer is washed with saturated sodium hydrogen carbonate solution
5. dry with materialdried over anhydrous magnesium sulfate
6. customevaporated to dryness in vacuo