反应详情

To a solution of 100 mg (0.23 mmol) 17-hydroxywortmannin and triethylamine (65 μL, 0.46 mmol) in 2 mL CH2Cl2 is added 4-(methylamino)butyric acid hydrochloride (71 mg, 0.46 mmol). The reaction mixture is stirred at room temperature for 12 hours and then concentrated in vacuo. The residue is dissolved in EtOAc and precipitated with hexane. The precipitate is washed two times with hexane to give the product as a yellow solid. MS (ESI) m/z 549 (M+H).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue is dissolved in EtOAc
3. customprecipitated with hexane
4. washThe precipitate is washed two times with hexane