Sodium Carbonate → HCID 86598986, compound

HRID 1446049Notes

Reaction equation

HRID 1446049 reaction equation
C1C=CC2SN=C(N3CCNCC3)C=2C=1.Cl.[C:17]([O-:20])([O-:19])=[O:18].[Na+:21].[Na+].[O-:23][S:24]([O-:27])(=[O:26])=[O:25].[Na+].[Na+].C1C=CC2SN=C(N3CCN(CCC4C=C5CC(=O)NC5=CC=4Cl)CC3)C=2C=1>O>[OH2:18].[C:17]([O-:20])([O-:19])=[O:18].[Na+:21].[Na+:21].[O-:26][S:24]([O-:27])(=[O:25])=[O:23].[Na+:21].[Na+:21]

Participants

6

Reactant 4

HCID 10340Sodium CarbonateHCID 24436Sodium SulfateHCID 60854ZiprasidoneHCID 115217113-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride

Product 1

HCID 86598986HCID 86598986, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a three necked flask was charged BITP HCl (10 g), CEI (10.35 g) Na2CO3 (14.1 g), Na2SO4 (40 g) and water (50.7 g) and the reaction mixture was heated at reflux for 9 hours. After 9 hours reflux, the ziprasidone peak is 71% area from the reaction mixture.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 9 hours
  3. temperatureAfter 9 hours reflux

Sources & evidence

ORD record
ord-c3a11c7126244ea09205d3f3f5152f3b
Source dataset
uspto-grants-2010_02
Patent number
US07667037B2

Reaction notes

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