Pyrrolidine → HCID 24809925, compound

HRID 1446173Notes

Reaction equation

HRID 1446173 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][N:13]=[CH:12][C:11]=2[C:15]([OH:17])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:14][N:13]=[CH:12][C:11]=2[C:15]([N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:17])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 228317075-(4-Nitrophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 24809925HCID 24809925, compound

Procedure

The title compound was prepared from 5-(4-nitrophenyl)isoxazole-4-carboxylic acid (11.7 mg, 0.050 mmol) and pyrrolidine (4.3 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (13.4 mg). MS (pos) m/z 288.2 (M+H).

Workup

  1. custompurified, first by preparative HPLC method A

Sources & evidence

ORD record
ord-0a858d63f8ee41e7ab79a7a25c461986
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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