Pyrrolidine → HCID 24809926, compound

HRID 1446174Notes

Reaction equation

HRID 1446174 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[NH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:16])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 49979625-(4-methoxyphenyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809926HCID 24809926, compound

Procedure

The title compound was prepared from 5-(4-methoxyphenyl)isoxazole-4-carboxylic acid (11.0 mg, 0.050 mmol) and pyrrolidine (4.3 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (15.1 mg). MS (pos) m/z 273.2 (M+H).

Workup

  1. custompurified, first by preparative HPLC method A

Sources & evidence

ORD record
ord-2c53a254977b45b590ff10842533614c
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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