4-(Trifluoromethoxy)benzylamine → HCID 24809929, compound

HRID 1446177Notes

Reaction equation

HRID 1446177 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)[CH:5]=[CH:6][CH:7]=1.[F:16][C:17]([F:28])([F:27])[O:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([NH:24][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([O:18][C:17]([F:16])([F:27])[F:28])=[CH:20][CH:21]=2)=[O:15])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 228316955-(3-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 24809929HCID 24809929, compound

Procedure

The title compound was prepared from 5-(3-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 4-(trifluoromethoxy)benzylamine (11.5 mg, 0.060 mmol) as described in synthetic method A and thereafter purified by preparative HPLC method B to give a solid (4.5 mg). MS (pos) m/z 397.0 (M+H).

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-2e455710aeaf4a9aaf73ac55e9b8362b
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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