3-(Trifluoromethyl)piperidine → HCID 24809958, compound

HRID 1446180Notes

Reaction equation

HRID 1446180 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:16]1[CH2:21][NH:20][CH2:19][CH:18]([C:22]([F:25])([F:24])[F:23])[CH2:17]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:20]2[CH2:21][CH2:16][CH2:17][CH:18]([C:22]([F:25])([F:24])[F:23])[CH2:19]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809958HCID 24809958, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and DL-3-(trifluoromethyl)piperidine (9.2 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.2 mg). HRMS calcd for C17H17F3N2O2: 338.1242, found 338.1242.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a0e4a34903cb49528d3a40e66f614bb6
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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