3-Hydroxypiperidine → HCID 24809959, compound

HRID 1446182Notes

Reaction equation

HRID 1446182 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[OH:16][CH:17]1[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:19]2[CH2:20][CH2:21][CH2:22][CH:17]([OH:16])[CH2:18]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 232933-HydroxypiperidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809959HCID 24809959, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-hydroxypiperidine (6.1 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (0.6 mg). HRMS calcd for C16H18N2O3: 286.1317, found 286.1315.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a4809bedcf914039a7837d0c56235fef
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…