4-Phenylpiperidin-4-ol → HCID 24809960, compound

HRID 1446183Notes

Reaction equation

HRID 1446183 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[OH:16][C:17]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:20]2[CH2:19][CH2:18][C:17]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([OH:16])[CH2:22][CH2:21]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809960HCID 24809960, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 4-hydroxy-4-phenylpiperidine (10.6 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (3.9 mg). HRMS calcd for C22H22N2O3: 362.1630, found 362.1623.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-2b368c88a7204c87b89c66a5ed659394
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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