4-(Trifluoromethyl)piperidine hydrochloride → HCID 24809985, compound

HRID 1446186Notes

Reaction equation

HRID 1446186 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[F:17][C:18]([F:26])([F:25])[CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:22]2[CH2:23][CH2:24][CH:19]([C:18]([F:26])([F:25])[F:17])[CH2:20][CH2:21]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 162181604-(Trifluoromethyl)piperidine hydrochlorideHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809985HCID 24809985, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 4-(trifluoromethyl)piperidine hydrochloride (9.2 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (8.5 mg). Calcd for C17H17F3N2O2: 338.1242, found 338.1238.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-9d3d6e6556654a5da9468f1bdcc7b27f
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…