Diisoamylamine → N,N-bis(3-Methylbutyl)-5-(4-methylphenyl)isoxazole-4-carboxamide

HRID 1446189Notes

Reaction equation

HRID 1446189 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:16]([NH:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:17][CH:18]([CH3:20])[CH3:19]>>[CH3:25][CH:24]([CH3:26])[CH2:23][CH2:22][N:21]([CH2:16][CH2:17][CH:18]([CH3:20])[CH3:19])[C:13]([C:9]1[CH:10]=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)=[O:15]

Participants

3

Reactant 2

HCID 10988DiisoamylamineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809988N,N-bis(3-Methylbutyl)-5-(4-methylphenyl)isoxazole-4-carboxamide

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and diisoamylamine (9.4 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (6.7 mg). Calcd for C21H30N2O2: 342.2307, found 342.2318.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-65be3168079b4b989590e792c965aca7
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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