3,3-Difluoropiperidine hydrochloride → HCID 24810017, compound

HRID 1446196Notes

Reaction equation

HRID 1446196 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[F:17][C:18]1([F:24])[CH2:23][CH2:22][CH2:21][NH:20][CH2:19]1>>[F:17][C:18]1([F:24])[CH2:23][CH2:22][CH2:21][N:20]([C:13]([C:9]2[CH:10]=[N:11][O:12][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=2)=[O:15])[CH2:19]1

Participants

3

Reactant 2

HCID 27583493,3-Difluoropiperidine hydrochlorideHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24810017HCID 24810017, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3,3-difluoropiperidine hydrochloride (9.5 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.4 mg). Calcd for C16H16F2N2O2: 306.1180, found 306.1177.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-ece69187a4844135b0e97ec646ef6e77
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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