4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 24810018, compound

HRID 1446197Notes

Reaction equation

HRID 1446197 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2([OH:29])[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2([OH:29])[CH2:24][CH2:25][N:26]([C:13]([C:9]3[CH:10]=[N:11][O:12][C:8]=3[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)=[O:15])[CH2:27][CH2:28]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24810018HCID 24810018, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 4-(4-chlorophenyl)-4-hydroxypiperidine (12.7 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (8.2 mg). Calcd for C22H21ClN2O3: 396.1241, found 396.1239.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-eb4ea6b8f53e4004a6368f75c8a10680
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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