1-(2-Pyrimidinyl)piperazine → HCID 24810019, compound

HRID 1446198Notes

Reaction equation

HRID 1446198 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:25]2[CH2:26][CH2:27][N:22]([C:17]3[N:16]=[CH:21][CH:20]=[CH:19][N:18]=3)[CH2:23][CH2:24]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24810019HCID 24810019, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 1-(2-pyrimidyl)piperazine (9.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.4 mg). Calcd for C19H19N5O2: 349.1539, found 349.1538.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-9e40ff4ed4a3416ebacd4bd83c12be82
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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