Oxalic acid--3-(4-methoxyphenyl)pyrrolidine (1/1) → HCID 24809509, compound

HRID 1446204Notes

Reaction equation

HRID 1446204 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.C(O)(=O)C(O)=O.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH:30]2[CH2:34][CH2:33][NH:32][CH2:31]2)=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([CH:30]2[CH2:34][CH2:33][N:32]([C:13]([C:9]3[CH:10]=[N:11][O:12][C:8]=3[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)=[O:15])[CH2:31]2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 17749747Oxalic acid--3-(4-methoxyphenyl)pyrrolidine (1/1)HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809509HCID 24809509, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-methoxyphenyl)pyrrolidine oxalat (16.0 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (4.3 mg). Calcd for C22H22N2O3: 362.1630, found 362.1636.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a4eac07f6d054ea198491677ae610957
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…