3-[(4-Fluorophenyl)methyl]pyrrolidine--hydrogen chloride (1/1) → HCID 59170061, compound

HRID 1446214Notes

Reaction equation

HRID 1446214 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[F:17][C:18]1[CH:29]=[CH:28][C:21]([CH2:22][CH:23]2[CH2:27][CH2:26][NH:25][CH2:24]2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][CH:23]2[CH2:27][CH2:26][N:25]([C:13]([C:9]3[CH:10]=[N:11][O:12][C:8]=3[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)=[O:15])[CH2:24]2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 177497543-[(4-Fluorophenyl)methyl]pyrrolidine--hydrogen chloride (1/1)HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170061HCID 59170061, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(4-fluorobenzyl)pyrrolidine hydrochloride (12.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (6.3 mg). Calcd for C22H21FN2O2: 364.1587, found 364.1604.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-ea9a82d2ec0b44dab798be83c9f891c6
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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