5-(p-Tolyl)isoxazole-4-carboxylic acid → HCID 59170150, compound

HRID 1446219Notes

Reaction equation

HRID 1446219 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[C:17]1([S:23]([CH:26]2[CH2:30][CH2:29][NH:28][CH2:27]2)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:28]2[CH2:29][CH2:30][CH:26]([S:23]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)(=[O:25])=[O:24])[CH2:27]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acidHCID 441187183-(Phenylsulfonyl)pyrrolidine hydrochloride

Product 1

HCID 59170150HCID 59170150, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(benzenesulfonyl)pyrrolidine hydrochloride (12.7 mg, 0.051 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.5 mg). Calcd for C21H20N2O4S: 396.1144, found 396.1142.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-113955815cc34da3accca14c2d7a2cb5
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…