HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(p-Tolyl)isoxazole-4-carboxylic acid → 5-(4-Methylphenyl)-4-{[3-(phenylsulfonyl)pyrrolidin-1-yl]carbonyl}isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Reactant | 3-(Phenylsulfonyl)pyrrolidine hydrochloride | HCID 44118718 | — |
| Product | 5-(4-Methylphenyl)-4-{[3-(phenylsulfonyl)pyrrolidin-1-yl]carbonyl}isoxazole | HCID 59170150 | — |
Reaction Steps
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 3-(benzenesulfonyl)pyrrolidine hydrochloride (12.7 mg, 0.051 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.5 mg). Calcd for C21H20N2O4S: 396.1144, found 396.1142.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-113955815cc34da3accca14c2d7a2cb5 |
| Source note | uspto-grants-2010_02 |