4-(4-(Trifluoromethyl)phenoxy)piperidine → 1-{[5-(4-Methylphenyl)isoxazol-4-yl]carbonyl}-4-[4-(trifluoromethyl)phenoxy]piperidine

HRID 1446221Notes

Reaction equation

HRID 1446221 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:30]=[CH:29][C:21]([O:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:20][CH:19]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:26]2[CH2:25][CH2:24][CH:23]([O:22][C:21]3[CH:20]=[CH:19][C:18]([C:17]([F:16])([F:31])[F:32])=[CH:30][CH:29]=3)[CH2:28][CH2:27]2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 36883924-(4-(Trifluoromethyl)phenoxy)piperidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 591701681-{[5-(4-Methylphenyl)isoxazol-4-yl]carbonyl}-4-[4-(trifluoromethyl)phenoxy]piperidine

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 4-[4-(trifluoromethyl)phenoxy]piperidine (16.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.6 mg). Calcd for C23H21F3N2O3: 430.1504, found 430.1510.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-889fa70465164688b421606c9f4b2b14
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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