HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-(Trifluoromethyl)phenoxy)piperidine → 1-{[5-(4-Methylphenyl)isoxazol-4-yl]carbonyl}-4-[4-(trifluoromethyl)phenoxy]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-(Trifluoromethyl)phenoxy)piperidine | HCID 3688392 | — |
| Reactant | 5-(p-Tolyl)isoxazole-4-carboxylic acid | HCID 22831706 | — |
| Product | 1-{[5-(4-Methylphenyl)isoxazol-4-yl]carbonyl}-4-[4-(trifluoromethyl)phenoxy]piperidine | HCID 59170168 | — |
Reaction Steps
The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and 4-[4-(trifluoromethyl)phenoxy]piperidine (16.9 mg, 0.060 mmol) as described in synthetic method B and thereafter purified by preparative HPLC method B to give a solid (11.6 mg). Calcd for C23H21F3N2O3: 430.1504, found 430.1510.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-889fa70465164688b421606c9f4b2b14 |
| Source note | uspto-grants-2010_02 |