3-(Trifluoromethyl)piperidine → HCID 59170045, compound

HRID 1446230Notes

Reaction equation

HRID 1446230 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[CH2:16]1[CH2:21][NH:20][CH2:19][CH:18]([C:22]([F:25])([F:24])[F:23])[CH2:17]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:20]1[CH2:21][CH2:16][CH2:17][CH:18]([C:22]([F:25])([F:24])[F:23])[CH2:19]1)=[O:15]

Participants

3

Reactant 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170045HCID 59170045, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and DL-3-(trifluoromethyl)piperidine (9.2 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (11.6 mg). Calcd for C16H14ClF3N2O2: 358.0696, found 358.0702.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-6d31dfe7e565484e8ed1c81317cb3c51
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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