HCID 17998818, compound → HCID 59170056, compound

HRID 1446235Notes

Reaction equation

HRID 1446235 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.C(O)(=O)C(O)=O.[F:22][C:23]([F:37])([F:36])[C:24]1[CH:35]=[CH:34][C:27]([CH2:28][CH:29]2[CH2:33][CH2:32][NH:31][CH2:30]2)=[CH:26][CH:25]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:31]1[CH2:32][CH2:33][CH:29]([CH2:28][C:27]2[CH:34]=[CH:35][C:24]([C:23]([F:22])([F:36])[F:37])=[CH:25][CH:26]=2)[CH2:30]1)=[O:15]

Participants

3

Reactant 2

HCID 17998818HCID 17998818, compoundHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170056HCID 59170056, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-[4-(trifluoromethyl)benzyl]pyrrolidine oxalate (19.2 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (9.2 mg). Calcd for C22H18ClF3N2O2: 434.1009, found 434.1003.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-8ac42fb714f945278638b1f050a115c8
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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