3-(Pyrrolidin-3-yl)pyridine → 3-(1-{[5-(2-Chlorophenyl)isoxazol-4-yl]carbonyl}pyrrolidin-3-yl)pyridine

HRID 1446237Notes

Reaction equation

HRID 1446237 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[NH:16]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:17]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:16]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:17]1)=[O:15]

Participants

3

Reactant 2

HCID 36136513-(Pyrrolidin-3-yl)pyridineHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 591700653-(1-{[5-(2-Chlorophenyl)isoxazol-4-yl]carbonyl}pyrrolidin-3-yl)pyridine

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-pyrrolidin-3-ylpyridine (8.9 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (8.0 mg). Calcd for C19H16ClN3O2: 353.0931, found 353.0932.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a5a242eda8f04967ad2f61357d0fe1c9
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…