5-Ethyl-2-methylpiperidine → 1-{[5-(2-Chlorophenyl)isoxazol-4-yl]carbonyl}-5-ethyl-2-methylpiperidine

HRID 1446238Notes

Reaction equation

HRID 1446238 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[CH2:16]([CH:18]1[CH2:23][NH:22][CH:21]([CH3:24])[CH2:20][CH2:19]1)[CH3:17]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:22]1[CH2:23][CH:18]([CH2:16][CH3:17])[CH2:19][CH2:20][CH:21]1[CH3:24])=[O:15]

Participants

3

Reactant 2

HCID 77275-Ethyl-2-methylpiperidineHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 591701691-{[5-(2-Chlorophenyl)isoxazol-4-yl]carbonyl}-5-ethyl-2-methylpiperidine

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 5-ethyl-2-methylpiperidine (7.6 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (2.8 mg). Calcd for C18H21ClN2O2: 332.1292, found 332.1293.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-84d0e09911444e619d73e2709d7a725a
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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