Oxalic acid--3-(4-methoxyphenyl)pyrrolidine (1/1) → HCID 59170227, compound

HRID 1446247Notes

Reaction equation

HRID 1446247 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.C(O)(=O)C(O)=O.[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([CH:33]2[CH2:37][CH2:36][NH:35][CH2:34]2)=[CH:29][CH:28]=1>>[CH3:25][O:26][C:27]1[CH:28]=[CH:29][C:30]([CH:33]2[CH2:37][CH2:36][N:35]([C:14]([C:10]3[CH:11]=[N:12][O:13][C:9]=3[C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=3)=[O:16])[CH2:34]2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 17749747Oxalic acid--3-(4-methoxyphenyl)pyrrolidine (1/1)HCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170227HCID 59170227, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 3-(4-methoxyphenyl)pyrrolidine oxalat (16.0 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (6.5 mg). Calcd for C22H19F3N2O3: 416.1348, found 416.1348.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-8aab4b07a7ec4c4aaa4f303b0f326fd9
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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