1003561-85-0 → HCID 59170241, compound

HRID 1446249Notes

Reaction equation

HRID 1446249 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.Cl.[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]2[S:31][CH2:30][CH2:29][NH:28][CH2:27]2)[CH:21]=1>>[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]2[S:31][CH2:30][CH2:29][N:28]([C:14]([C:10]3[CH:11]=[N:12][O:13][C:9]=3[C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=3)=[O:16])[CH2:27]2)[CH:21]=1

Participants

3

Reactant 2

HCID 177498141003561-85-0HCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170241HCID 59170241, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 2-pyridin-3-yl thiomorpholine hydrochloride (13.0 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (12.8 mg). Calcd for C20H16F3N3O2S: 419.0915, found 419.0914.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-fcaa74faefe843f1a05125b4d09d37b4
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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