3-(Trifluoromethyl)piperidine → HCID 59170226, compound

HRID 1446252Notes

Reaction equation

HRID 1446252 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH2:19]1[CH2:24][NH:23][CH2:22][CH:21]([C:25]([F:28])([F:27])[F:26])[CH2:20]1>>[F:26][C:25]([F:28])([F:27])[CH:21]1[CH2:20][CH2:19][CH2:24][N:23]([C:14]([C:10]2[CH:11]=[N:12][O:13][C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=2)=[O:16])[CH2:22]1

Participants

3

Reactant 2

HCID 27607763-(Trifluoromethyl)piperidineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170226HCID 59170226, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and DL-3-(trifluoromethyl)piperidine (9.2 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (11.8 mg). Calcd for C17H14F6N2O2: 392.0959, found 392.0959.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-c6cd6f61f8b24a0fa247e3e052fc7846
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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