(2R)-2-(Methoxymethyl)pyrrolidine → HCID 59170049, compound

HRID 1446259Notes

Reaction equation

HRID 1446259 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH3:19][O:20][CH2:21][C@H:22]1[CH2:26][CH2:25][CH2:24][NH:23]1>>[CH3:19][O:20][CH2:21][C@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[C:14]([C:10]1[CH:11]=[N:12][O:13][C:9]=1[C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=1)=[O:16]

Participants

3

Reactant 2

HCID 671216(2R)-2-(Methoxymethyl)pyrrolidineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170049HCID 59170049, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and (R)-2-methoxymethyl-pyrrolidine (6.9 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (10.1 mg). Calcd for C17H17F3N2O3: 354.1191, found 354.1190.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-738752d06f6b4c928c5a547bdffc22b6
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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