4-Benzylpiperidine → 4-Benzyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine

HRID 1446260Notes

Reaction equation

HRID 1446260 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH2:19]([CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([CH:26]1[CH2:31][CH2:30][N:29]([C:14]([C:10]2[CH:11]=[N:12][O:13][C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=2)=[O:16])[CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 317384-BenzylpiperidineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 591700974-Benzyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 4-benzylpiperidine (10.5 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (13.4 mg). Calcd for C23H21F3N2O2: 414.1555, found 414.1544.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a3e909b0be1c41978a00367ea194ec1e
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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