HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzylpiperidine → 4-Benzyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzylpiperidine | HCID 31738 | — |
| Reactant | 4-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]- | HCID 68682921 | — |
| Product | 4-Benzyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine | HCID 59170097 | — |
Reaction Steps
The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 4-benzylpiperidine (10.5 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (13.4 mg). Calcd for C23H21F3N2O2: 414.1555, found 414.1544.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-a3e909b0be1c41978a00367ea194ec1e |
| Source note | uspto-grants-2010_02 |