反应详情

To 5-(4-methylphenyl)isoxazole-4-carbonyl chloride (21 mg, 0.068 mmol) in dichloromethane (1 mL) was added 4-phenylpiperidine (17 mg, 0.068 mmol, 1 eq.), and the reaction mixture was stirred for 1 h. The solvent was removed, and the residue was purified by preparative reverse-phase HPLC to give the title compound. HRMS (ESI, pos. ion) m/z calcd for C22H22N2O2: 346.1681, found 346.1685.

1. customThe solvent was removed
2. customthe residue was purified by preparative reverse-phase HPLC