Ethanol → HCID 55262964, compound

HRID 1446535Notes

Reaction equation

HRID 1446535 reaction equation
C(O)C.[Cl:4][C:5]1[CH:6]=[C:7]([CH2:12][N:13]2C(=O)C3C(=CC=CC=3)C2=O)[C:8]([CH3:11])=[N:9][CH:10]=1.O.NN>C(OCC)C>[Cl:4][C:5]1[CH:6]=[C:7]([CH2:12][NH2:13])[C:8]([CH3:11])=[N:9][CH:10]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 66960207HCID 66960207, compound

Product 1

HCID 55262964HCID 55262964, compoundYield 119%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To an ethanol (10 mL) solution of 2-((5-chloro-2-methyl-pyridine-3-yl)methyl)isoindole-1,3-dione (0.20 g), hydrazine monohydrate (0.50 mL) was added, and heat-refluxing of the reaction solution was carried out for 2 hours. The reaction solution was allowed to be cooled to room temperature, diethyl ether (50 mL) was added to the reaction solution, and the reaction solution was agitated for 30 minutes at room temperature. C-(5-chloro-2-methylpyridin-3-yl)methylamine (0.13 g) was obtained by filtering off insoluble matters in the reaction solution and condensing the obtained filtrate under reduced pressure.

Workup

  1. temperatureheat-refluxing of the reaction solution

Sources & evidence

ORD record
ord-b99f3a4b298a44e39348272dd3a2b68c
Source dataset
uspto-grants-2010_02
Patent number
US07667041B2

Reaction notes

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