Ethanol → HCID 66961610, compound

Participants

Reaction Steps

Triethylamine (45 mL) was added to an ethanol (80 mL) solution of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (3.0 g) and (1-acetyl-2-oxopyrrolidin-3-yl)triphenylphosphonyl bromide (8.4 g) synthesized by the method described in Journal of Medicinal Chemistry, vol. 30, No. 11, p. 1995, 1987. The reaction solution was made to react at 60° C. for 2 hours. The reaction solution was cooled to room temperature and was added to a mixed-solution of ethyl acetate and iced water. The deposited solids were dried under reduced pressure after separated by filtration, and 3.3 g of the title compound was obtained. The physical properties of the compound are as follows.

Provenance & Evidence