Ethanol → HCID 66961610, compound

HRID 1446543Notes

Reaction equation

HRID 1446543 reaction equation
[CH2:1]([N:3](CC)[CH2:4][CH3:5])[CH3:2].[CH2:8]([OH:10])[CH3:9].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[N:21]1[CH:25]=[C:24]([CH3:26])[N:23]=[CH:22]1)[CH:16]=O.C(OCC)(=[O:29])C>O>[C:8]([N:3]1[CH2:4][CH2:5]/[C:2](=[CH:16]\[C:15]2[CH:18]=[CH:19][C:20]([N:21]3[CH:25]=[C:24]([CH3:26])[N:23]=[CH:22]3)=[C:13]([O:12][CH3:11])[CH:14]=2)/[C:1]1=[O:29])(=[O:10])[CH3:9]

Participants

6

Reactant 4

HCID 702EthanolHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 272824453-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 66961610HCID 66961610, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Triethylamine (45 mL) was added to an ethanol (80 mL) solution of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (3.0 g) and (1-acetyl-2-oxopyrrolidin-3-yl)triphenylphosphonyl bromide (8.4 g) synthesized by the method described in Journal of Medicinal Chemistry, vol. 30, No. 11, p. 1995, 1987. The reaction solution was made to react at 60° C. for 2 hours. The reaction solution was cooled to room temperature and was added to a mixed-solution of ethyl acetate and iced water. The deposited solids were dried under reduced pressure after separated by filtration, and 3.3 g of the title compound was obtained. The physical properties of the compound are as follows.

Workup

  1. customsynthesized by the method
  2. customto react at 60° C. for 2 hours
  3. customThe deposited solids were dried under reduced pressure
  4. customafter separated by filtration

Sources & evidence

ORD record
ord-282967398f4e4e1496fd7987538837c9
Source dataset
uspto-grants-2010_02
Patent number
US07667041B2

Reaction notes

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