HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [2-Fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68543160 | HCID 68543160 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [2-Fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid dihydrochloride | HCID 68543260 | — |
Reaction Steps
Suspend [2-fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid tert-butyl ester (1.36 g, 3.369 mmol) in water (8 mL) and 4N hydrochloric acid in dioxane (40 mL) and stir at ambient temperature for 3 hours. Concentration under vacuum quantitatively provides the title compound (1.42 g, 3.69 mmol). MS(ES), m/z 348 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666879B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-2750dad25de547bfab666c346edf3d35 |
| Source note | uspto-grants-2010_02 |