Hydrochloric Acid → [2-Fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid dihydrochloride

HRID 1446724Notes

Reaction equation

HRID 1446724 reaction equation
C([O:5][C:6](=[O:30])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:18]3[CH:19]=[CH:20][C:21]([C:23]4[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=4)=[CH:22][C:17]3=[N:16][CH:15]=2)=[CH:10][C:9]=1[F:29])(C)(C)C.[ClH:31]>O.O1CCOCC1>[ClH:31].[ClH:31].[F:29][C:9]1[CH:10]=[C:11]([C:14]2[N:18]3[CH:19]=[CH:20][C:21]([C:23]4[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=4)=[CH:22][C:17]3=[N:16][CH:15]=2)[CH:12]=[CH:13][C:8]=1[CH2:7][C:6]([OH:30])=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68543160HCID 68543160, compound

Product 1

HCID 68543260[2-Fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid dihydrochloride

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Suspend [2-fluoro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetic acid tert-butyl ester (1.36 g, 3.369 mmol) in water (8 mL) and 4N hydrochloric acid in dioxane (40 mL) and stir at ambient temperature for 3 hours. Concentration under vacuum quantitatively provides the title compound (1.42 g, 3.69 mmol). MS(ES), m/z 348 (M+1).

Workup

  1. concentrationConcentration under vacuum

Sources & evidence

ORD record
ord-2750dad25de547bfab666c346edf3d35
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

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