反应详情

温度

70 °C

Combine 7-[2-(4-methyl-piperazin-1-yl)-pyrimidin-5-yl]-3-(4-nitro-phenyl)-imidazo[1,2-a]pyridine (0.372 g, 0.895 mmol), iron(III) chloride (0.007 g, 0.045 mmol), and 1,1-dimethylhydrazine (0.68 mL, 8.95 mmol) in methanol (10 mL). Attach a reflux condenser, and heat the mixture to 70° C., stir overnight (15 hours), and cool to room temperature. Slurry the mixture into additional methanol and filter through Celite® 521. Concentrate the solution in vacuo to afford yellow solid intermediate amine, 4-{7-[2-(4-methyl-piperazin-1-yl)-pyrimidin-5-yl]-imidazo[1,2-a]pyridin-3-yl}-phenylamine. Use as is. MS(ES), m/z 386 (M+1)

1. temperaturecool to room temperature
2. filtrationSlurry the mixture into additional methanol and filter through Celite® 521
3. concentrationConcentrate the solution in vacuo