HCID 68541667, compound → HCID 57863431, compound

HRID 1446766Notes

Reaction equation

HRID 1446766 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:39])[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[N:23]4[CH:24]=[CH:25][C:26]([C:28]5[CH:29]=[N:30][N:31](S(=O)(=O)N(C)C)[CH:32]=5)=[CH:27][C:22]4=[N:21][CH:20]=3)=[CH:15][CH:14]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C(Cl)Cl.CO.Cl.CCOCC.CC(O)=O>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:39])[CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]3[N:23]4[CH:24]=[CH:25][C:26]([C:28]5[CH:29]=[N:30][NH:31][CH:32]=5)=[CH:27][C:22]4=[N:21][CH:20]=3)=[CH:17][CH:18]=2)[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

7

Reactant 1

HCID 68541667HCID 68541667, compound

Product 1

HCID 57863431HCID 57863431, compound

Reagents, catalysts & solvents 5

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Dissolve N-(5-tert-Butyl-isoxazol-3-yl)-2-{4-[7-(1-dimethylsulfamoyl-1H-pyrazol-4-yl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-acetamide in CH2Cl2, methanol and 1 N HCl in ether in equal volumes and then concentrate to give a solid. Dissolve the solid in HOAc and stir for 1 hour. Concentrate and purify by silica gel chromatography with 0-5% MeOH in CH2Cl2. MS(ES), m/z 441 (M+1).

Workup

  1. concentrationconcentrate
  2. customto give a solid
  3. concentrationConcentrate
  4. custompurify by silica gel chromatography with 0-5% MeOH in CH2Cl2

Sources & evidence

ORD record
ord-8f38c61f0e6f475497c7a34e9a8515bc
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

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