Formic Acid → N-(2,5-difluorophenyl)formamide

HRID 1446776Notes

Reaction equation

HRID 1446776 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:3]=1[NH2:4].[CH:10](O)=[O:11]>C1C=CC=CC=1>[F:1][C:2]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:3]=1[NH:4][CH:10]=[O:11]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 677752,5-Difluoroaniline

Product 1

HCID 12803461N-(2,5-difluorophenyl)formamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 25.8 g of 2A, 18.5 g of formic acid and 100 ml of benzene was refluxed (80° C.) for 2 hours. The mixture was allowed to stand overnight. The solid that formed was separated and taken up in ether. Hexane was added. The solid that formed was separated and washed with cold hexane to give N-(2,5-difluorophenyl)formamide (2B), m.p.: 112°-114° C.

Workup

  1. customThe solid that formed
  2. customwas separated
  3. additionHexane was added
  4. customThe solid that formed
  5. customwas separated
  6. washwashed with cold hexane

Sources & evidence

ORD record
ord-2991f509d6354ab99b2a11bdfcbaa4f7
Source dataset
uspto-grants-1982_02
Patent number
US04313755

Reaction notes

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