HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1446776Generated: October 26, 2026
Formic Acid → N-(2,5-difluorophenyl)formamide
https://huagongshe.com/reaction/1446776
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 2,5-Difluoroaniline | HCID 67775 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-(2,5-difluorophenyl)formamide | HCID 12803461 | — |
Reaction Steps
A mixture of 25.8 g of 2A, 18.5 g of formic acid and 100 ml of benzene was refluxed (80° C.) for 2 hours. The mixture was allowed to stand overnight. The solid that formed was separated and taken up in ether. Hexane was added. The solid that formed was separated and washed with cold hexane to give N-(2,5-difluorophenyl)formamide (2B), m.p.: 112°-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04313755 |
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| Source dataset | uspto-grants-1982_02 |
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| ORD ID | ord-2991f509d6354ab99b2a11bdfcbaa4f7 |
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| Source note | uspto-grants-1982_02 |
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