Dimethylformamide → N'-cyclopropyl-N-(2,5-difluorophenyl)-N-formylurea

Participants

Reaction Steps

A mixture of 9.9 g of 2B, 25 ml of dimethylformamide, 11 g of 1A and 2 g of triethylamine (catalyst) was heated in a steam bath for 24 hours. The resulting mixture was diluted with ether and water, and phase-separated. The ether phase was washed with water, and dried (MgSO4), and the solvent was evaporated. The residue was triturated with ether. The residual off-white solid was 2, m.p.: 118°-120° C.

Provenance & Evidence