反应详情

A mixture of 94 parts of 2-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione, 21 parts of 1,2-ethanediol, 3 parts of 4-methylbenzenesulfonic acid, 40 parts of 1-butanol and 450 parts of methylbenzene is stirred and refluxed for 15 hours using a waterseparator. The reaction mixture is cooled and washed with a diluted sodium hydroxide solution. The organic phase is dried, filtered and evaporated. The solid residue is triturated in 2,2'-oxybispropane. The product is filtered off and dried, yielding 102 parts of 2-[2-(4-methoxyphenyl)-1,3-dioxolan-2-ylmethyl]-1H-isoindole-1,3(2H)-dione

1. temperaturerefluxed for 15 hours
2. temperatureThe reaction mixture is cooled
3. washwashed with a diluted sodium hydroxide solution
4. customThe organic phase is dried
5. filtrationfiltered
6. customevaporated
7. customThe solid residue is triturated in 2,2'-oxybispropane
8. filtrationThe product is filtered off
9. customdried