反应详情

A mixture of 7 parts of 1-ethyl-2-(4-methoxyphenyl)-1H-imidazole monohydrochloride and 75 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed for 2 hours. The reaction mixture is concentrated and a small amount of water is added to the concentrate. The whole is neutralized with sodium hydrogen carbonate. The precipitated product is filtered off and crystallized from a mixture of ethanol and water, yielding 3.3 parts of 4-(1-ethyl-1H-imidazol-2-yl)phenol.

1. temperaturerefluxed for 2 hours
2. concentrationThe reaction mixture is concentrated
3. additiona small amount of water is added to the concentrate
4. filtrationThe precipitated product is filtered off
5. customcrystallized from a mixture of ethanol and water