反应详情

A mixture of 2-chlorobenzimidazole (1.0 g), 4-(N-methylamino)phenol (1.13 g) and acetonitrile/water (1:1) was heated under reflux for a period of 5 hours. The mixture was concentrated, made basic with dilute ammonium hydroxide and the solid was collected. The product was recrystallised from ethanol to give 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol (0.92 g) as colourless crystals, mp>260° C.

1. temperaturewas heated
2. temperatureunder reflux for a period of 5 hours
3. concentrationThe mixture was concentrated
4. customthe solid was collected
5. customThe product was recrystallised from ethanol