HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-Methyl-p-aminophenol → 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-Methyl-p-aminophenol | HCID 5931 | — |
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol | HCID 13314818 | 58.7% |
Reaction Steps
A mixture of 2-chlorobenzimidazole (1.0 g), 4-(N-methylamino)phenol (1.13 g) and acetonitrile/water (1:1) was heated under reflux for a period of 5 hours. The mixture was concentrated, made basic with dilute ammonium hydroxide and the solid was collected. The product was recrystallised from ethanol to give 4-[N-methyl-N-(2-benzimidazolyl)amino]phenol (0.92 g) as colourless crystals, mp>260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04314065 |
| Source dataset | uspto-grants-1982_02 |
| ORD ID | ord-fac870d124ac453eb09f7b0f90d47b6a |
| Source note | uspto-grants-1982_02 |