反应详情

温度

50 °C

2-Mercaptobenzoxazole (6.0 g, 0.04 mole) was slowly added, with stirring, to a solution of sodium methoxide prepared by the addition of sodium (1.0 g) to anhydrous methanol (150 ml). Methyl iodide (5 ml) was added and the mixture was stirred at a temperature of 50° C. for a period of 3 hours and allowed to stand overnight at room temperature. The methanol was removed by distillation under reduced pressure and the solid residue was triturated with ice water and the insoluble material was collected by filtration. The solid was dissolved in chloroform, dried over anhydrous magnesium sulfate and the solvent removed to give 2-(methylthio)benoxazole (5.8 g) as a brown oil.

1. waitto stand overnight at room temperature
2. customThe methanol was removed by distillation under reduced pressure
3. customthe solid residue was triturated with ice water
4. filtrationthe insoluble material was collected by filtration
5. dissolutionThe solid was dissolved in chloroform
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvent removed
8. customto give 2-(methylthio)benoxazole (5.8 g) as a brown oil