Hydrochloric Acid → HCID 20551770, compound

Participants

Reaction Steps

To the 4.9 grams of the 3-[5-[1-methoxy-1-methylethyl]-1,3,4-thiadiazol-2-yl]-1-methyl-(2,2-dimethoxyethyl)urea (prepared above) was added 150 milliliters of water and 1.5 milliliters of concentrated hydrochloric acid (HCl). The resulting solution was refluxed for 5 minutes, and the aqueous phase was extracted twice with 50 milliliters of chloroform (CHCl3). The 100 milliliter chloroform extract was dried over anhydrous MgSO4, filtered and topped on a roto-vac at 70° C. to yield 3.0 grams of a yellow oil of 3-[5-(1-methoxy-1-methylethyl)-1,3,4-thiadiazol-2-yl]-1-methyl-4-hydroxy-2-imidazolidinone with an

Provenance & Evidence